HMM Summary Page: TIGR00846

Functioncalcium/proton exchanger
Gene SymbolchaA
Trusted Cutoff317.45
Domain Trusted Cutoff317.45
Noise Cutoff188.25
Domain Noise Cutoff188.25
Isology Typesuperfamily
HMM Length372
Mainrole CategoryTransport and binding proteins
Subrole CategoryCations and iron carrying compounds
AuthorPaulsen IT, Saier MH, Loftus BJ
Entry DateJul 25 2000 6:19PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19) Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria. All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange. This Hmm is generated from the calcium ion/proton exchangers of the CacA family.
ReferencesA2 hmmalign SE Ipaulsen AL clustalw_manual