HMM Summary Page: TIGR00845

Functionsodium/calcium exchanger 1
Trusted Cutoff679.85
Domain Trusted Cutoff679.85
Noise Cutoff553.05
Domain Noise Cutoff553.05
Isology Typeequivalog
HMM Length921
Mainrole CategoryTransport and binding proteins
Subrole CategoryOther
Gene Ontology TermGO:0005432: calcium:sodium antiporter activity molecular_function
GO:0005887: integral to plasma membrane cellular_component
GO:0006814: sodium ion transport biological_process
GO:0006816: calcium ion transport biological_process
GO:0006874: cellular calcium ion homeostasis biological_process
GO:0006883: cellular sodium ion homeostasis biological_process
AuthorPaulsen IT, Saier MH, Loftus BJ
Entry DateJul 25 2000 6:19PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19) Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria. All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange. This Hmm is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family
ReferencesA2 hmmalign SE Ipaulsen AL clustalw_manual