HMM Summary Page: TIGR00840

Functionsodium/hydrogen exchanger 3
Gene Symbolnhe-3
Trusted Cutoff251.25
Domain Trusted Cutoff251.25
Noise Cutoff245.60
Domain Noise Cutoff245.60
Isology Typeequivalog
HMM Length559
Mainrole CategoryTransport and binding proteins
Subrole CategoryCations and iron carrying compounds
Gene Ontology TermGO:0005887: integral to plasma membrane cellular_component
GO:0006814: sodium ion transport biological_process
GO:0006883: cellular sodium ion homeostasis biological_process
GO:0006885: regulation of pH biological_process
GO:0015385: sodium:hydrogen antiporter activity molecular_function
AuthorPaulsen IT, Saier MH, Loftus BJ
Entry DateJul 25 2000 6:19PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36) The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals. Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in (1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles. This Hmm is specific for the eukaryotic members members of this family.
ReferencesA2 hmmalign SE Ipaulsen AL clustalw_manual