HMM Summary Page: TIGR00834

Functionanion exchange protein
Trusted Cutoff599.45
Domain Trusted Cutoff599.45
Noise Cutoff445.45
Domain Noise Cutoff445.45
Isology Typesubfamily
HMM Length900
Mainrole CategoryTransport and binding proteins
Subrole CategoryAnions
AuthorPaulsen IT, Saier MH, Loftus BJ
Entry DateJul 25 2000 6:19PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe Anion Exchanger (AE) Family (TC 2.A.31) Characterized protein members of the AE family are found only in animals. They preferentially catalyze anion exchange (antiport) reactions, typically acting as HCO3-:Cl- antiporters, but also transporting a range of other inorganic and organic anions. Additionally, renal Na+:HCO3- cotransporters have been found to be members of the AE family. They catalyze the reabsorption of HCO3- in the renal proximal tubule.
ReferencesA2 hmmalign SE Ipaulsen AL clustalw_manual