HMM Summary Page: TIGR00833

Functiontransport protein
Trusted Cutoff874.70
Domain Trusted Cutoff874.70
Noise Cutoff244.55
Domain Noise Cutoff244.55
Isology Typesubfamily
HMM Length910
Mainrole CategoryTransport and binding proteins
Subrole CategoryUnknown substrate
AuthorPaulsen IT, Saier MH, Loftus BJ
Entry DateJul 25 2000 6:19PM
Last ModifiedMar 1 2011 11:50AM
CommentThe Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5) Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate.
ReferencesA2 hmmalign SE Ipaulsen AL clustalw_manual