| Accession | TIGR00824 |
| Name | EIIA-man |
| Function | PTS system, mannose/fructose/sorbose family, IIA component |
| Trusted Cutoff | 98.35 |
| Domain Trusted Cutoff | 98.35 |
| Noise Cutoff | 66.75 |
| Domain Noise Cutoff | 66.75 |
| Isology Type | subfamily_domain |
| EC Number | 2.7.1.69 |
| HMM Length | 116 |
| Mainrole Category | Transport and binding proteins |
| Subrole Category | Carbohydrates, organic alcohols, and acids |
| Author | Paulsen IT, Saier MH, Loftus BJ |
| Entry Date | Jul 25 2000 6:19PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains.The Man family is unique in several respects among PTS permease families It is the only PTS family in which members possess a IID protein. It is the only PTS family in which the IIB constituent is phosphorylated on a histidyl rather than a cysteyl residue. Its permease members exhibit broad specificity for a range of sugars, rather than being specific for just one or a few sugars. The mannose permease of E. coli, for example, can transport and phosphorylate glucose, mannose, fructose, glucosamine, N-acetylglucosamine, and other sugars. Other members of this can transport sorbose, fructose and N-acetylglucosamine. This family is specific for the IIA components. |
| References | SE ipaulsen
DR URL; http://www-biology.ucsd.edu/~msaier/transport/4_A_6.html |
| Genome Property | GenProp0119: PTS transport system (HMM) |
