HMM Summary Page: TIGR00820

FunctionZIP zinc/iron transport family
Gene Symbolzip
Trusted Cutoff231.15
Domain Trusted Cutoff231.15
Noise Cutoff168.40
Domain Noise Cutoff168.40
Isology Typesubfamily
HMM Length324
Mainrole CategoryTransport and binding proteins
Subrole CategoryCations and iron carrying compounds
AuthorPaulsen IT, Saier MH, Loftus BJ
Entry DateJul 7 2000 1:41PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP) Family (TC 2.A.5) Members of the ZIP family consist of proteins with eight putative transmembrane spanners. They are derived from animals, plants and yeast. They comprise a diverse family, with several paralogues in any one organism (e.g., at least five in Caenorabditis elegans, at least five in Arabidopsis thaliana and two in Saccharomyces cervisiae. The two S. cerevisiae proteins, Zrt1 and Zrt2, both probably transport Zn2+ with high specificity, but Zrt1 transports Zn2+ with ten-fold higher affinity than Zrt2. Some members of the ZIP family have been shown to transport Zn2+ while others transport Fe2+, and at least one transports a range of metal ions. The energy source for transport has not been characterized, but these systems probably function as secondary carriers.
ReferencesA2 hmmalign SE Ipaulsen AL clustalw_manual