HMM Summary Page: TIGR00816

FunctionC4-dicarboxylate transporter/malic acid transport protein
Gene Symboltdt
Trusted Cutoff237.25
Domain Trusted Cutoff237.25
Noise Cutoff121.50
Domain Noise Cutoff121.50
Isology Typesubfamily
HMM Length320
Mainrole CategoryTransport and binding proteins
Subrole CategoryCarbohydrates, organic alcohols, and acids
AuthorSaier MH, Paulsen IT, Loftus BJ
Entry DateJul 7 2000 1:41PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe Tellurite-Resistance/Dicarboxylate Transporter (TDT) Family (TC 2.A.16) Two members of the TDT family have been functionally characterized. One is the TehA protein of E. coli which has been implicated in resistance to tellurite; the other is the Mae1 protein of S. pombe which functions in the uptake of malate and other dicarboxylates by a proton symport mechanism. These proteins exhibit 10 putative transmembrane a-helical spanners (TMSs).
ReferencesA2 hmmalign SE Ipaulsen AL clustalw_manual