HMM Summary Page: TIGR00815

Functionsulfate permease
Gene SymbolsulP
Trusted Cutoff380.45
Domain Trusted Cutoff380.45
Noise Cutoff289.50
Domain Noise Cutoff289.50
Isology Typesubfamily
HMM Length565
Mainrole CategoryTransport and binding proteins
Subrole CategoryAnions
Gene Ontology TermGO:0008272: sulfate transport biological_process
GO:0015116: sulfate transmembrane transporter activity molecular_function
GO:0016020: membrane cellular_component
AuthorPaulsen IT, Saier MH, Loftus BJ
Entry DateJul 7 2000 1:41PM
Last ModifiedJul 18 2011 3:01PM
CommentThe SulP family is a large and ubiquitous family with over 30 sequenced members derived from bacteria, fungi, plants and animals. Many organisms including Bacillus subtilis, Synechocystis sp, Saccharomyces cerevisiae, Arabidopsis thaliana and Caenorhabditis elegans possess multiple SulP family paralogues. Many of these proteins are functionally characterized, and all are sulfate uptake transporters. Some transport their substrate with high affinities, while others transport it with relatively low affinities. Most function by SO42- :H+symport, but SO42- :HCO3- antiport has been reported for the rat protein (spP45380). The bacterial proteins vary in size from 434 residues to 566 residues with one exception, a Mycobacterium tuberculosis protein with 784 residues. The eukaryotic proteins vary in size from 611 residues to 893 residues with one exception, a protein designated "early nodulin 70 protein" from Glycine max which is reported to be of 485 residues. Thus, the eukaryotic proteins are almost without exception larger than the prokaryotic proteins. These proteins exhibit 10-13 putative transmembrane a-helical spanners (TMSs) depending on the protein. The phylogenetic tree for the SulP family reveals five principal branches. Three of these are bacterial specific as follows: one bears a single protein from M. tuberculosis; a second bears two proteins, one from M. tuberculosis, the other from Synechocystis sp, and the third bears all remaining prokaryotic proteins. The remaining two clusters bear only eukaryotic proteins with the animal proteins all localized to one branch and the plant and fungal proteins localized to the other. The generalized transport reactions catalyzed by SulP family proteins are: (1) SO42- (out) + nH+ (out) --> SO42- (in) + nH+ (in). (2) SO42- (out) + nHCO3- (in) SO42- (in) + nHCO3- (out).
ReferencesA2 hmmalign SE Ipaulsen AL clustalw_manual