HMM Summary Page: TIGR00813

Functiontransporter, solute:sodium symporter (SSS) family
Trusted Cutoff184.00
Domain Trusted Cutoff184.00
Noise Cutoff149.80
Domain Noise Cutoff149.80
Isology Typesuperfamily
HMM Length411
Mainrole CategoryTransport and binding proteins
Subrole CategoryCations and iron carrying compounds
Gene Ontology TermGO:0005887: integral to plasma membrane cellular_component
GO:0006810: transport biological_process
GO:0015370: solute:sodium symporter activity molecular_function
AuthorPaulsen IT, Saier MH, Loftus BJ
Entry DateJul 7 2000 1:41PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli.
ReferencesSE Ipaulsen DR HAMAP; MF_01426; 29 of 30