HMM Summary Page: TIGR00809

Functionprotein-export chaperone SecB
Gene SymbolsecB
Trusted Cutoff102.80
Domain Trusted Cutoff102.80
Noise Cutoff51.70
Domain Noise Cutoff51.70
Isology Typeequivalog
HMM Length140
Mainrole CategoryProtein fate
Subrole CategoryProtein and peptide secretion and trafficking
Gene Ontology TermGO:0005737: cytoplasm cellular_component
GO:0043952: protein transport by the Sec complex biological_process
GO:0050821: protein stabilization biological_process
GO:0051082: unfolded protein binding molecular_function
AuthorHaft DH
Entry DateJul 7 2000 1:41PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein acts as an export-specific cytosolic chaperone. It binds the mature region of pre-proteins destined for secretion, prevents aggregation, and delivers them to SecA. This protein is tetrameric in E. coli. The archaeal Methanococcus jannaschii homolog MJ0357 has been shown (PMID:14985117) to share many properties, including chaperone-like activity, and scores between trusted and noise.
ReferencesRM 98232496 RT The Escherichia coli SRP and SecB targeting pathways converge at the translocon. RA Valent QA, Scotti PA, High S, de Gier JW, von Heijne G, Lentzen G, Wintermeyer W, Oudega B, Luirink J RL EMBO J 1998 May 1;17(9):2504-12 DR EXPERIMENTAL; EGAD|9663|EC3609; Escherichia coli DR Interpro; IPR003708 DR PFAM; PF02556 DR HAMAP; MF_00821; 261 of 266
Genome PropertyGenProp0209: Sec system preprotein translocase (HMM)