| Accession | TIGR00809 |
| Name | secB |
| Function | protein-export chaperone SecB |
| Gene Symbol | secB |
| Trusted Cutoff | 102.80 |
| Domain Trusted Cutoff | 102.80 |
| Noise Cutoff | 51.70 |
| Domain Noise Cutoff | 51.70 |
| Isology Type | equivalog |
| HMM Length | 140 |
| Mainrole Category | Protein fate |
| Subrole Category | Protein and peptide secretion and trafficking |
| Gene Ontology Term | GO:0005737: cytoplasm cellular_component |
| | GO:0043952: protein transport by the Sec complex biological_process |
| | GO:0050821: protein stabilization biological_process |
| | GO:0051082: unfolded protein binding molecular_function |
| Author | Haft DH |
| Entry Date | Jul 7 2000 1:41PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This protein acts as an export-specific cytosolic chaperone. It binds the mature region of pre-proteins destined for secretion, prevents aggregation, and delivers them to SecA.
This protein is tetrameric in E. coli.
The archaeal Methanococcus jannaschii homolog MJ0357 has been shown (PMID:14985117) to share many properties, including chaperone-like activity, and scores between trusted and noise. |
| References | RM 98232496
RT The Escherichia coli SRP and SecB targeting pathways converge at the translocon.
RA Valent QA, Scotti PA, High S, de Gier JW, von Heijne G, Lentzen G, Wintermeyer W, Oudega B, Luirink J
RL EMBO J 1998 May 1;17(9):2504-12
DR EXPERIMENTAL; EGAD|9663|EC3609; Escherichia coli
DR Interpro; IPR003708
DR PFAM; PF02556
DR HAMAP; MF_00821; 261 of 266 |
| Genome Property | GenProp0209: Sec system preprotein translocase (HMM) |
