Accession | TIGR00806 |
Name | rfc |
Function | reduced folate carrier |
Gene Symbol | rfc |
Trusted Cutoff | 227.40 |
Domain Trusted Cutoff | 227.40 |
Noise Cutoff | 217.40 |
Domain Noise Cutoff | 217.40 |
Isology Type | equivalog |
HMM Length | 511 |
Mainrole Category | Transport and binding proteins |
Subrole Category | Carbohydrates, organic alcohols, and acids |
Gene Ontology Term | GO:0008517: folic acid transporter activity molecular_function |
| GO:0015884: folic acid transport biological_process |
Author | Paulsen IT, Saier MH, Loftus BJ |
Entry Date | Jul 7 2000 1:41PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | The Reduced Folate Carrier (RFC) Family (TC 2.A.48)
Members of the RFC family mediate the uptake of folate, reduce
folate, derivatives of reduced folate and the drug, methotrexate.
Proteins of the RFC family are so-far restricted to animals. RFC proteins possess 12 putative transmembrane a-helical spanners (TMSs) and evidence for a 12 TMS topology has been published for the human RFC. The RFC transporters appear to transport reduced folate by an energy-dependent, pH-dependent, Na+-independent mechanism. Folate:H+ symport, folate:OH- antiport and folate:anion antiport mechanisms have been proposed, but the energetic mechanism is not well defined. |
References | A2 hmmalign
SE Ipaulsen
AL clustalw_manual |