HMM Summary Page: TIGR00806

Functionreduced folate carrier
Gene Symbolrfc
Trusted Cutoff227.40
Domain Trusted Cutoff227.40
Noise Cutoff217.40
Domain Noise Cutoff217.40
Isology Typeequivalog
HMM Length511
Mainrole CategoryTransport and binding proteins
Subrole CategoryCarbohydrates, organic alcohols, and acids
Gene Ontology TermGO:0008517: folic acid transporter activity molecular_function
GO:0015884: folic acid transport biological_process
AuthorPaulsen IT, Saier MH, Loftus BJ
Entry DateJul 7 2000 1:41PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe Reduced Folate Carrier (RFC) Family (TC 2.A.48) Members of the RFC family mediate the uptake of folate, reduce folate, derivatives of reduced folate and the drug, methotrexate. Proteins of the RFC family are so-far restricted to animals. RFC proteins possess 12 putative transmembrane a-helical spanners (TMSs) and evidence for a 12 TMS topology has been published for the human RFC. The RFC transporters appear to transport reduced folate by an energy-dependent, pH-dependent, Na+-independent mechanism. Folate:H+ symport, folate:OH- antiport and folate:anion antiport mechanisms have been proposed, but the energetic mechanism is not well defined.
ReferencesA2 hmmalign SE Ipaulsen AL clustalw_manual