| Accession | TIGR00801 |
| Name | ncs2 |
| Function | uracil-xanthine permease |
| Trusted Cutoff | 291.80 |
| Domain Trusted Cutoff | 291.80 |
| Noise Cutoff | 202.10 |
| Domain Noise Cutoff | 202.10 |
| Isology Type | superfamily |
| HMM Length | 415 |
| Mainrole Category | Transport and binding proteins |
| Subrole Category | Nucleosides, purines and pyrimidines |
| Gene Ontology Term | GO:0015205: nucleobase transmembrane transporter activity molecular_function |
| | GO:0015851: nucleobase transport biological_process |
| | GO:0016021: integral to membrane cellular_component |
| Author | Paulsen IT, Saier MH, Loftus BJ |
| Entry Date | Jul 7 2000 1:40PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | The Nucleobase:Cation Symporter-2 (NCS2) Family (TC 2.A.40)
Most of the functionally characterized members of the NCS2 family are transporters specific for nucleobases including both purines and pyrimidines. However, two closely related rat members of the family, SVCT1 and SVCT2,
localized to different tissues of the body, cotransport L-ascorbate and Na+ with a high degree of specificity and high affinity for the vitamin. The
NCS2 family appears to be distantly related to the NCS1 family (TC #2.A.39). |
| References | A2 hmmalign
SE Ipaulsen
AL clustalw_manual |
