HMM Summary Page: TIGR00794

Functionpotassium uptake protein
Gene Symbolkup
Trusted Cutoff539.60
Domain Trusted Cutoff539.60
Noise Cutoff444.90
Domain Noise Cutoff444.90
Isology Typeequivalog
HMM Length688
Mainrole CategoryTransport and binding proteins
Subrole CategoryCations and iron carrying compounds
Gene Ontology TermGO:0006813: potassium ion transport biological_process
GO:0015079: potassium ion transmembrane transporter activity molecular_function
GO:0016020: membrane cellular_component
AuthorPaulsen IT, Saier MH, Loftus BJ
Entry DateJul 7 2000 1:40PM
Last ModifiedFeb 14 2011 3:27PM
CommentProteins of the KUP family include the KUP (TrkD) protein of E. coli, a partially sequenced ORF from Lactococcus lactis, high affinity K+ uptake systems (Hak1) of the yeast Debaryomyces occidentalis as well as the fungus, Neurospora crassa, and several homologues in plants. While the E. coli KUP protein is assumed to be a secondary transporter, and uptake is blocked by protonophores such as CCCP (but not arsenate), the energy coupling mechanism has not been defined. However, the N. crassa protein has been shown to be a K+:H+ symporter, establishing that the KUP family consists of secondary carriers. The plant high affinity (20mM) K+ transporter can complement K+ uptake defects in E. coli.
ReferencesSE Ipaulsen DR URL; DR Interpro; IPR003855 DR PFAM; PF2705 DR HAMAP; MF_01522; 37 of 248