HMM Summary Page: TIGR00792

Functionsugar (Glycoside-Pentoside-Hexuronide) transporter
Gene Symbolgph
Trusted Cutoff231.35
Domain Trusted Cutoff231.35
Noise Cutoff219.90
Domain Noise Cutoff219.90
Isology Typesubfamily_domain
HMM Length437
Mainrole CategoryTransport and binding proteins
Subrole CategoryCarbohydrates, organic alcohols, and acids
Gene Ontology TermGO:0006812: cation transport biological_process
GO:0008643: carbohydrate transport biological_process
GO:0015486: glycoside-pentoside-hexuronide:cation symporter activity molecular_function
GO:0016021: integral to membrane cellular_component
AuthorPaulsen IT, Saier MH, Loftus BJ
Entry DateJul 7 2000 1:40PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners.
ReferencesSE Ipaulsen