HMM Summary Page: TIGR00790

Functionformate/nitrite transporter
Gene Symbolfnt
Trusted Cutoff232.30
Domain Trusted Cutoff232.30
Noise Cutoff126.35
Domain Noise Cutoff126.35
Isology Typesubfamily
HMM Length239
Mainrole CategoryTransport and binding proteins
Subrole CategoryAnions
Gene Ontology TermGO:0006820: anion transport biological_process
GO:0008509: anion transmembrane transporter activity molecular_function
AuthorPaulsen IT, Saier MH, Loftus BJ
Entry DateJul 7 2000 1:40PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe Formate-Nitrite Transporter (FNT) Family (TC 2.A.44) The prokaryotic proteins of the FNT family probably function in the transport of the structurally related compounds, formate and nitrite. The homologous yeast protein may function as a short chain aliphatic carboxylate H+ symporter, transporting formate, acetate and propionate, and functioning primarily as an acetate uptake permease. The putative formate efflux transporters (FocA) of bacteria associated with pyruvate-formate lyase (pfl) comprise cluster I; the putative formate uptake permeases (FdhC) of bacteria and archaea associated with formate dehydrogenase comprise cluster II; the putative nitrite uptake permeases (NirC) of bacteria comprise cluster III, and the single yeast protein, the putative acetate:H+ symporter alone comprises cluster IV. The energy coupling mechanisms for proteins of the FNT family have not been extensively characterized. HCO2 -, CH3CO2 - and NO2 - uptakes are probably coupled to H+ symport. HCO2 - efflux may be driven by the membrane potential by a uniport mechanism or by H+ antiport.
ReferencesA2 hmmalign SE Ipaulsen AL clustalw_manual