HMM Summary Page: TIGR00778

Functionalkylhydroperoxidase AhpD family core domain
Trusted Cutoff27.80
Domain Trusted Cutoff27.80
Noise Cutoff13.30
Domain Noise Cutoff13.30
Isology Typedomain
HMM Length51
Mainrole CategoryUnknown function
Subrole CategoryGeneral
AuthorHaft DH
Entry DateJul 7 2000 1:40PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents a 51-residue core region of homology among a family of mostly uncharacterized proteins of 110 to 227 amino acids. Most members of this family contain the motif EXXXXXX[SA]XXXXXC[VIL]XCXXXH. Members of the family include the alkylhydroperoxidase AhpD of Mycobacterium tuberculosis, a macrophage infectivity potentiator peptide of Legionella pneumophila, and an uncharacterized peptide in the tetrachloroethene reductive dehalogenase operon of Dehalospirillum multivorans. We suggest that many peptides containing this domain may have alkylhydroperoxidase or related antioxidant activity.
ReferencesAL clustalw_manual RN [1] RT The AhpC and AhpD Antioxidant Defense System of Mycobacterium tuberculosis. RA Hillas PJ, del Alba FS, Oyarzabal J, Wilks A, Ortiz De Montellano PR RL J Biol Chem 2000 Jun 16;275(25):18801-18809 DR HAMAP; MF_01676; 46 of 48