| Accession | TIGR00777 |
| Name | ahpD |
| Function | alkylhydroperoxidase, AhpD family |
| Gene Symbol | ahpD |
| Trusted Cutoff | 191.95 |
| Domain Trusted Cutoff | 191.95 |
| Noise Cutoff | 94.80 |
| Domain Noise Cutoff | 94.80 |
| Isology Type | subfamily |
| EC Number | 1.11.1.15 |
| HMM Length | 177 |
| Mainrole Category | Cellular processes |
| Subrole Category | Detoxification |
| Author | Haft DH, Dodson RJ |
| Entry Date | Jul 7 2000 1:40PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this family are alkylhydroperoxidases, which catalyze the reduction of peroxides to their corresponding alcohols via oxidation of cysteine residues. In these alkylhydroperoxidases, the cysteines are located in a conserved -CXXC- motif located towards the COOH terminus. In Mycobacterium tuberculosis, two non-homologous alkylhydroperoxidases, AhpD and AhpC, are found in the same operon. |
| References | RN [1]
RT The AhpC and AhpD Antioxidant Defense System of Mycobacterium tuberculosis.
RA Hillas PJ, del Alba FS, Oyarzabal J, Wilks A, Ortiz De Montellano PR
RL J Biol Chem 2000 Jun 16;275(25):18801-18809
DR HAMAP; MF_01676; 41 of 48 |
| Genome Property | GenProp0213: Resistance to Reactive Oxygen Species (ROS) (HMM) |
