HMM Summary Page: TIGR00777

Functionalkylhydroperoxidase, AhpD family
Gene SymbolahpD
Trusted Cutoff191.95
Domain Trusted Cutoff191.95
Noise Cutoff94.80
Domain Noise Cutoff94.80
Isology Typesubfamily
EC Number1.11.1.15
HMM Length177
Mainrole CategoryCellular processes
Subrole CategoryDetoxification
AuthorHaft DH, Dodson RJ
Entry DateJul 7 2000 1:40PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are alkylhydroperoxidases, which catalyze the reduction of peroxides to their corresponding alcohols via oxidation of cysteine residues. In these alkylhydroperoxidases, the cysteines are located in a conserved -CXXC- motif located towards the COOH terminus. In Mycobacterium tuberculosis, two non-homologous alkylhydroperoxidases, AhpD and AhpC, are found in the same operon.
ReferencesRN [1] RT The AhpC and AhpD Antioxidant Defense System of Mycobacterium tuberculosis. RA Hillas PJ, del Alba FS, Oyarzabal J, Wilks A, Ortiz De Montellano PR RL J Biol Chem 2000 Jun 16;275(25):18801-18809 DR HAMAP; MF_01676; 41 of 48
Genome PropertyGenProp0213: Resistance to Reactive Oxygen Species (ROS) (HMM)