HMM Summary Page: TIGR00773

FunctionNa+/H+ antiporter NhaA
Gene SymbolnhaA
Trusted Cutoff254.00
Domain Trusted Cutoff254.00
Noise Cutoff220.55
Domain Noise Cutoff220.55
Isology Typeequivalog
HMM Length374
Mainrole CategoryTransport and binding proteins
Subrole CategoryCations and iron carrying compounds
Gene Ontology TermGO:0006814: sodium ion transport biological_process
GO:0006818: hydrogen transport biological_process
GO:0015385: sodium:hydrogen antiporter activity molecular_function
AuthorPaulsen IT, Saier MH, Loftus BJ
Entry DateJul 7 2000 1:40PM
Last ModifiedFeb 14 2011 3:27PM
CommentThese proteins are members of the NhaA Na+:H+ Antiporter (NhaA) Family (TC. 2.A.33). The Escherichia coli NhaA protein probably functions in the regulation of the internal pH when the external pH is alkaline. It also uses the H+ gradient to expel Na+ from the cell. Its activity is highly pH dependent. Only the E. coli protein is functionally and structurally well characterized.
ReferencesDR InterPro; IPR000676 SE Ipaulsen DR URL; DR HAMAP; MF_01844; 242 of 254