HMM Summary Page: TIGR00771

Functiontransporter, anaerobic C4-dicarboxylate uptake C (DcuC) family
Trusted Cutoff187.00
Domain Trusted Cutoff187.00
Noise Cutoff148.50
Domain Noise Cutoff148.50
Isology Typesubfamily
HMM Length388
Mainrole CategoryTransport and binding proteins
Subrole CategoryCarbohydrates, organic alcohols, and acids
Gene Ontology TermGO:0005887: integral to plasma membrane cellular_component
GO:0015556: C4-dicarboxylate transmembrane transporter activity molecular_function
GO:0015740: C4-dicarboxylate transport biological_process
AuthorPaulsen IT, Saier MH, Loftus BJ
Entry DateJul 7 2000 1:40PM
Last ModifiedFeb 14 2011 3:27PM
CommentThese proteins are members of the C4-dicarboxylate Uptake C (DcuC) Family (TC 2.A.61). The only functionally characterized member of this family is the anaerobic C4-dicarboxylate transporter (DcuC) of Escherichia coli. DcuC has 12 GES predicted transmembrane regions, is induced only under anaerobic conditions, and is not repressed by glucose. It may therefore function as a succinate efflux system during anaerobic glucose fermentation. However, when overexpressed, it can replace either DcuA or DcuB in catalyzing fumarate-succinate exchange and fumarate uptake.
ReferencesSE Ipaulsen DR URL;