HMM Summary Page: TIGR00770

Functiontransporter, anaerobic C4-dicarboxylate uptake (Dcu) family
Trusted Cutoff331.35
Domain Trusted Cutoff331.35
Noise Cutoff248.70
Domain Noise Cutoff248.70
Isology Typesubfamily
HMM Length430
Mainrole CategoryTransport and binding proteins
Subrole CategoryCarbohydrates, organic alcohols, and acids
Gene Ontology TermGO:0005887: integral to plasma membrane cellular_component
GO:0015556: C4-dicarboxylate transmembrane transporter activity molecular_function
GO:0015740: C4-dicarboxylate transport biological_process
AuthorPaulsen IT, Saier MH, Loftus BJ
Entry DateJul 7 2000 1:40PM
Last ModifiedFeb 14 2011 3:27PM
CommentThese proteins are members of th C4-Dicarboxylate Uptake (Dcu) Family (TC 2.A.13). Most proteins in this family have 12 GES predicted transmembrane regions; however one member has 10 experimentally determined transmembrane regions with both the N- and C-termini localized to the periplasm. The two Escherichia coli proteins, DcuA and DcuB, transport aspartate, malate, fumarate and succinate, and function as antiporters with any two of these substrates. Since DcuA is encoded in an operon with the gene for aspartase, and DcuB is encoded in an operon with the gene for fumarase, their physiological functions may be to catalyze aspartate:fumarate and fumarate:malate exchange during the anaerobic utilization of aspartate and fumarate, respectively.
ReferencesSE Ipaulsen DR URL;