HMM Summary Page: TIGR00765

FunctionYihY family inner membrane protein
Gene SymbolyihY
Trusted Cutoff73.15
Domain Trusted Cutoff73.15
Noise Cutoff43.25
Domain Noise Cutoff43.25
Isology Typesubfamily_domain
HMM Length259
Mainrole CategoryUnknown function
Subrole CategoryGeneral
Gene Ontology TermGO:0003674: molecular_function molecular_function
GO:0005575: cellular_component cellular_component
GO:0008150: biological_process biological_process
AuthorHaft DH
Entry DateJun 13 2000 5:57PM
Last ModifiedDec 8 2011 11:33AM
CommentInitial identification of members of this protein family was based on characterization of the yihY gene product as ribonuclease BN in Escherichia coli. This identification has been withdrawn, as the group now finds the homolog in E. coli of RNase Z is the true ribonuclease BN rather than a strict functional equivalent of RNase Z. Members of this subfamily include the largely uncharacterized BrkB (Bordetella resist killing by serum B) from Bordetella pertussis. Some members have an additional C-terminal domain. Paralogs from E. coli (yhjD) and Mycobactrium tuberculosis (Rv3335c) are part of a smaller, related subfamily that form their own cluster.
ReferencesDR EXPERIMENTAL; EGAD:17695; Escherichia coli DR OUTGROUP; EGAD|10508|EC3522; Escherichia coli DR OUTGROUP; EGAD|160884|Rv3335c; Mycobacterium tuberculosis RN [1] RM 15764599 RT The RNase Z homologue encoded by Escherichia coli elaC gene is RNase BN. RA Ezraty B, Dahlgren B, Deutscher MP. RL J Biol Chem. 2005 Apr 29;280(17):16542-5. RN [2] RM 20092870 RT Purification and characterization of the tRNA-processing enzyme RNase BN. RA Callahan C, Neri-Cortes D, Deutscher MP RL J Biol Chem 2000 Jan 14;275(2):1030-4 RN [3] RM 93015723 RT The presence of only one of five exoribonucleases is sufficient to support the growth of Escherichia coli. RA Kelly KO, Deutscher MP RL J Bacteriol 1992 Oct;174(20):6682-4 DR HAMAP; MF_00672; 73 of 74