HMM Summary Page: TIGR00762

FunctionEDD domain protein, DegV family
Trusted Cutoff99.70
Domain Trusted Cutoff99.70
Noise Cutoff84.10
Domain Noise Cutoff84.10
Isology Typedomain
HMM Length276
Mainrole CategoryUnknown function
Subrole CategoryGeneral
Gene Ontology TermGO:0005575: cellular_component cellular_component
GO:0008150: biological_process biological_process
GO:0016740: transferase activity molecular_function
AuthorHaft DH, Dodson RJ
Entry DateJun 13 2000 5:57PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family of proteins is related to DegV of Bacillus subtilis and includes paralogous sets in several species (B. subtilis, Deinococcus radiodurans, Mycoplasma pneumoniae) that are closer in percent identity to each than to most homologs from other species. This suggests both recent paralogy and diversity of function. DegV itself is encoded immediately downstream of DegU, a transcriptional regulator of degradation, but is itself uncharacterized. Crystallography suggested a lipid-binding site, while comparison of the crystal structure to dihydroxyacetone kinase and to a mannose transporter EIIA domain suggests a conserved domain, EDD, with phosphotransferase activity.
ReferencesRN [1] RM PMID:15632288 RT EDD, a novel phosphotransferase domain common to mannose transporter EIIA, dihydroxyacetone kinase, and DegV. RA Kinch LN, Cheek S, Grishin NV RL Protein Sci. 2005 Feb;14(2):360-7.