HMM Summary Page: TIGR00759

Functionpyruvate dehydrogenase (acetyl-transferring), homodimeric type
Gene SymbolaceE
Trusted Cutoff859.90
Domain Trusted Cutoff859.90
Noise Cutoff436.60
Domain Noise Cutoff436.60
Isology Typeequivalog
EC Number1.2.4.1
HMM Length885
Gene Ontology TermGO:0004738: pyruvate dehydrogenase activity molecular_function
GO:0006086: acetyl-CoA biosynthetic process from pyruvate biological_process
GO:0045250: cytosolic pyruvate dehydrogenase complex cellular_component
AuthorHaft DH
Entry DateJun 13 2000 5:57PM
Last ModifiedFeb 14 2011 3:27PM
CommentMost members of this family are pyruvate dehydrogenase complex, E1 component. Note: this family was classified as subfamily rather than equivalog because it includes a counterexample from Pseudomonas putida, MdeB, that is active as an E1 component of an alpha-ketoglutarate dehydrogenase complex rather than a pyruvate dehydrogase complex. The second pyruvate dehydrogenase complex E1 protein from Alcaligenes eutrophus, PdhE, complements an aceE mutant of E. coli but is not part of a pyruvate dehydrogenase complex operon, is more similar to the Pseudomonas putida MdeB than to E. coli AceE, and may have also have a different primary specificity.
ReferencesRN [1] RM 97334115 RT Molecular characterization of the mde operon involved in L-methionine catabolism of Pseudomonas putida. RA Inoue H, Inagaki K, Eriguchi SI, Tamura T, Esaki N, Soda K, Tanaka H RL J Bacteriol 1997 Jun;179(12):3956-62