HMM Summary Page: TIGR00758

Functionuracil-DNA glycosylase, family 4
Trusted Cutoff125.30
Domain Trusted Cutoff125.30
Noise Cutoff27.10
Domain Noise Cutoff27.10
Isology Typesubfamily
EC Number3.2.2.-
HMM Length173
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0004844: uracil DNA N-glycosylase activity molecular_function
GO:0006281: DNA repair biological_process
AuthorHaft DH, Dodson RJ
Entry DateJun 13 2000 5:57PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis well-conserved family of proteins is about 200 residues in length and homologous to the N-terminus of the DNA polymerase of phage SPO1 of Bacillus subtilis. The member from Thermus thermophilus HB8 is known to act as uracil-DNA glycosylase, an enzyme of DNA base excision repair. Its appearance as a domain of phage DNA polymerases could be consistent with uracil-DNA glycosylase activity.
ReferencesRN [1] RM 14556741 RT Crystal structure of a family 4 uracil-DNA glycosylase from Thermus thermophilus HB8. RA Hoseki J, Okamoto A, Masui R, Shibata T, Inoue Y, Yokoyama S, Kuramitsu S. RL J Mol Biol. 2003 Oct 24;333(3):515-26. RN [2] RM 92380475 RT The DNA polymerase-encoding gene of Bacillus subtilis bacteriophage SPO1 RA Scarlato V, Gargano S RL Gene 1992 Sep 1;118(1):109-13