HMM Summary Page: TIGR00755

Functionribosomal RNA small subunit methyltransferase A
Gene SymbolrsmA
Trusted Cutoff171.00
Domain Trusted Cutoff171.00
Noise Cutoff168.00
Domain Noise Cutoff168.00
Isology Typeequivalog
EC Number2.1.1.182
HMM Length256
Mainrole CategoryProtein synthesis
Subrole CategorytRNA and rRNA base modification
Gene Ontology TermGO:0000154: rRNA modification biological_process
GO:0000179: rRNA (adenine-N6,N6-)-dimethyltransferase activity molecular_function
AuthorHaft DH
Entry DateApr 11 2000 5:53PM
Last ModifiedFeb 14 2011 3:27PM
CommentIn both E. coli and Saccharomyces cerevisiae, this protein is responsible for the dimethylation of two adjacent adenosine residues in a conserved hairpin of 16S rRNA in bacteria, 18S rRNA in eukaryotes. This adjacent dimethylation is the only rRNA modification shared by bacteria and eukaryotes. A single member of this family is present in each of the first 20 completed microbial genomes. This protein is essential in yeast, but not in E. coli, where its deletion leads to resistance to the antibiotic kasugamycin. Alternate name: S-adenosylmethionine--6-N',N'-adenosyl (rRNA) dimethyltransferase
ReferencesAL clustalw_manual DR EXPERIMENTAL; EGAD|18707|EC0051; Escherichia coli; ksgA DR EXPERIMENTAL; EGAD|56477|YPL266W; Saccharomyces cerevisiae; DIM1 DR COGS; COG0030 RN [1] RM 94343533 RT The DIM1 gene responsible for the conserved m6(2)Am6(2)A dimethylation in the 3'-terminal loop of 18 S rRNA is essential in yeast. RA Lafontaine D, Delcour J, Glasser AL, Desgres J, Vandenhaute J RL J Mol Biol 1994 Aug 19;241(3):492-7 DR HAMAP; MF_00607; 470 of 476
Genome PropertyGenProp0799: bacterial core gene set, exactly 1 per genome (HMM)
GenProp0802: ribosome biogenesis proteins, bacteria (HMM)