HMM Summary Page: TIGR00753

Functionundecaprenyl-diphosphatase UppP
Gene SymboluppP
Trusted Cutoff217.50
Domain Trusted Cutoff217.50
Noise Cutoff107.90
Domain Noise Cutoff107.90
Isology Typeequivalog
EC Number3.6.1.27
HMM Length255
Mainrole CategoryCell envelope
Subrole CategoryBiosynthesis and degradation of murein sacculus and peptidoglycan
Gene Ontology TermGO:0009252: peptidoglycan biosynthetic process biological_process
GO:0030288: outer membrane-bounded periplasmic space cellular_component
GO:0046677: response to antibiotic biological_process
GO:0050380: undecaprenyl-diphosphatase activity molecular_function
AuthorLoftus BJ, Haft DH
Entry DateMar 2 2000 2:33PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis is a family of small, highly hydrophobic proteins. Overexpression of this protein in Escherichia coli is associated with bacitracin resistance, and the protein was originally proposed to be an undecaprenol kinase and called bacA. It is now known to be an undecaprenyl pyrophosphate phosphatase (EC and is renamed UppP.
ReferencesDR InterPro; IPR003824 RN [1] RM PMID:15138271 RT The bacA gene of Escherichia coli encodes an undecaprenyl pyrophosphate phosphatase activity. RA El Ghachi M, Bouhss A, Blanot D, Mengin-Lecreulx D RL J Biol Chem. 2004 Jul 16;279(29):30106-13. RN [2] RM PMID: 8389741 RT Amplification of the bacA gene confers bacitracin resistance to Escherichia coli. RA Cain BD, Norton PJ, Eubanks W, Nick HS, Allen CM RL J Bacteriol 1993 Jun;175(12):3784-9 DR HAMAP; MF_01006; 348 of 485
Genome PropertyGenProp0971: biosynthesis of undecaprenyl phosphate (Und-P) (HMM)