HMM Summary Page: TIGR00750

FunctionLAO/AO transport system ATPase
Trusted Cutoff240.75
Domain Trusted Cutoff240.75
Noise Cutoff157.75
Domain Noise Cutoff157.75
Isology Typeequivalog
EC Number2.7.-.-
HMM Length300
Mainrole CategoryTransport and binding proteins
Subrole CategoryAmino acids, peptides and amines
Gene Ontology TermGO:0015809: arginine transport biological_process
GO:0015819: lysine transport biological_process
GO:0015822: ornithine transport biological_process
GO:0016772: transferase activity, transferring phosphorus-containing groups molecular_function
AuthorLoftus BJ, Haft DH
Entry DateMar 2 2000 2:33PM
Last ModifiedFeb 14 2011 3:27PM
CommentIn E. coli, mutation of this kinase blocks phosphorylation of two transporter system periplasmic binding proteins and consequently inhibits those transporters. This kinase is also found in Gram-positive bacteria, archaea, and the roundworm C. elegans. It may have a more general, but still unknown function. Mutations have also been found that do not phosphorylate the periplasmic binding proteins, yet still allow transport. The ATPase activity of this protein seems to be necessary, however.
ReferencesSE AL clustalw_manual A2 hmmalign SE COG/EC_num RN [1] RM 90110251 RT Purification and properties of a kinase from Escherichia coli K-12 that phosphorylates two periplasmic transport proteins. RA Urban C, Celis RT RL J Biol Chem 1990 Jan 25;265(3):1783-6 RN [2] RM 90110252 RT Mutant of Escherichia coli K-12 with defective phosphorylation of two periplasmic transport proteins. RA Celis RT RL J Biol Chem 1990 Jan 25;265(3):1787-93