| Accession | TIGR00748 |
| Name | HMG_CoA_syn_Arc |
| Function | putative hydroxymethylglutaryl-CoA synthase |
| Trusted Cutoff | 353.35 |
| Domain Trusted Cutoff | 353.35 |
| Noise Cutoff | 353.15 |
| Domain Noise Cutoff | 353.15 |
| Isology Type | equivalog |
| EC Number | 2.3.3.10 |
| HMM Length | 345 |
| Mainrole Category | Fatty acid and phospholipid metabolism |
| Subrole Category | Biosynthesis |
| Gene Ontology Term | GO:0004315: 3-oxoacyl-[acyl-carrier-protein] synthase activity molecular_function |
| | GO:0006633: fatty acid biosynthetic process biological_process |
| Author | Selengut J, Haft DH |
| Entry Date | Mar 2 2000 2:33PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This family of archaeal proteins shows considerable homology and identical active site residues to the bacterial hydroxymethylglutaryl-CoA synthase (HMG-CoA synthase, modeled by TIGR01835) which is the second step in the mevalonate pathway of IPP biosynthesis [1].
An enzyme from Pseudomonas fluorescens involved in the biosynthesis of the polyketide diacetyl-phloroglucinol is more closely related, but lacks the active site residues [2].
In each of the genomes containing a member of this family there is no other recognized HMG-CoA synthase, although other elements of the mevalonate pathway are in evidence. The only archaeon currently sequenced which lacks a homolog in this pathway is Halobacterium, which _does_ contain a separate HMG-CoA synthase.
Thus, although there is no experimental evidence supporting this name, the bioinformatics-based conclusion appears to be sound. |
| References | RN [1]
RM PMID: 12107122
RT Enterococcus faecalis 3-hydroxy-3-methylglutaryl coenzyme A synthase, an enzyme of isopentenyl diphosphate biosynthesis.
RA Sutherlin A, Hedl M, Sanchez-Neri B, Burgner JW 2nd, Stauffacher CV, Rodwell VW.
RL J Bacteriol. 2002 Aug;184(15):4065-70.
RN [2]
RM PMID: 10322017
RT Identification and characterization of a gene cluster for synthesis of the polyketide antibiotic 2,4-diacetylphloroglucinol from Pseudomonas fluorescens Q2-87.
RA Bangera MG, Thomashow LS.
RL J Bacteriol. 1999 May;181(10):3155-63.
DR HAMAP; MF_01409; 30 of 30 |
| Genome Property | GenProp0047: IPP biosynthesis via mevalonate (HMM) |
