HMM Summary Page: TIGR00747

Function3-oxoacyl-[acyl-carrier-protein] synthase III
Gene SymbolfabH
Trusted Cutoff292.10
Domain Trusted Cutoff292.10
Noise Cutoff135.65
Domain Noise Cutoff135.65
Isology Typesubfamily
EC Number2.3.1.180
HMM Length322
Mainrole CategoryFatty acid and phospholipid metabolism
Subrole CategoryBiosynthesis
Gene Ontology TermGO:0004315: 3-oxoacyl-[acyl-carrier-protein] synthase activity molecular_function
GO:0006633: fatty acid biosynthetic process biological_process
AuthorHaft DH, Loftus BJ
Entry DateMar 2 2000 2:33PM
Last ModifiedFeb 14 2011 7:55PM
CommentFabH in general initiate elongation in type II fatty acid synthase systems found in bacteria and plants. The two members of this subfamily from Bacillus subtilis differ from each other, and from FabH from E. coli, in acyl group specificity. Active site residues include Cys112, His244 and Asn274 of E. coli FabH. Cys-112 is the site of acyl group attachment.
ReferencesSE EC_num AL clustalw DR EXPERIMENTAL; EGAD|23257|EC1091; Escherichia coli DR EXPERIMENTAL; EGAD|22159|22835; Rhodobacter capsulatus DR EXPERIMENTAL; EGAD|60481|63308; spinach RN [1] RM 20096678 RT beta-ketoacyl-acyl carrier protein synthase III (FabH) is a determining factor in branched-chain fatty acid biosynthesis. RA Choi KH, Heath RJ, Rock CO RL J Bacteriol 2000 Jan;182(2):365-70 RN [2] RT The 1.8 A crystal structure and active-site architecture of beta-ketoacyl-acyl carrier protein synthase III (FabH) from Escherichia coli. RA Davies C, Heath RJ, White SW, Rock CO RL Structure Fold Des 2000;8(2):185-195 RN [3] RM 94291939 DR HAMAP; MF_01815; 327 of 330
Genome PropertyGenProp0681: fatty acid biosynthesis from acetyl-CoA (HMM)