HMM Summary Page: TIGR00746

Functioncarbamate kinase
Gene SymbolarcC
Trusted Cutoff358.25
Domain Trusted Cutoff358.25
Noise Cutoff41.85
Domain Noise Cutoff41.85
Isology Typeequivalog
EC Number2.7.2.2
HMM Length309
Mainrole CategoryEnergy metabolism
Subrole CategoryAmino acids and amines
Gene Ontology TermGO:0006520: cellular amino acid metabolic process biological_process
GO:0008804: carbamate kinase activity molecular_function
AuthorHaft DH, Loftus BJ
Entry DateMar 2 2000 2:33PM
Last ModifiedFeb 14 2011 3:27PM
CommentIn most species, carbamate kinase works in arginine catabolism and consumes carbamoyl phosphate to convert ADP into ATP. In the pathway in Pyrococcus furiosus, the enzyme acts instead to generate carbamoyl phosphate. The seed alignment for this model includes experimentally confirmed examples from a set of phylogenetically distinct species. In a neighbor-joining tree constructed from an alignment of candidate carbamate kinases and several acetylglutamate kinases, the latter group forms a clear outgroup which roots the tree of carbamate kinase-like proteins. This analysis suggests that in E. coli, the ArcC paralog YqeA may be a second isozyme, while the paralog YahI branches as an outlier and is less likely to be an authentic carbamate kinase. The homolog from Mycoplasma pneumoniae likewise branches outside the set containing known carbamate kinases and also scores below the trusted cutoff.
ReferencesA2 hmmalign SE COG AL clustalw_manual DR EXPERIMENTAL; GP|2764613|emb|CAA04684.1||AJ001330; Lactobacillus sake DR EXPERIMENTAL; EGAD|43354|45784; Halobacterium salinarium DR EXPERIMENTAL; EGAD|9324|9129; Pseudomonas aeruginosa DR EXPERIMENTAL; GP|4102922|gb|AAD13336.1||AF017784; Giardia intestinalis DR EXPERIMENTAL; GP|3687419|emb|CAA76780.1||Y17554; Bacillus licheniformis RM 99278397
Genome PropertyGenProp0639: arginine degradation via citrulline, ATP-generating (HMM)
GenProp0687: allantoin catabolism to oxamate and carbamoyl-phosphate (HMM)