| Accession | TIGR00746 |
| Name | arcC |
| Function | carbamate kinase |
| Gene Symbol | arcC |
| Trusted Cutoff | 358.25 |
| Domain Trusted Cutoff | 358.25 |
| Noise Cutoff | 41.85 |
| Domain Noise Cutoff | 41.85 |
| Isology Type | equivalog |
| EC Number | 2.7.2.2 |
| HMM Length | 309 |
| Mainrole Category | Energy metabolism |
| Subrole Category | Amino acids and amines |
| Gene Ontology Term | GO:0006520: cellular amino acid metabolic process biological_process |
| | GO:0008804: carbamate kinase activity molecular_function |
| Author | Haft DH, Loftus BJ |
| Entry Date | Mar 2 2000 2:33PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | In most species, carbamate kinase works in arginine catabolism and consumes carbamoyl phosphate to convert ADP into ATP. In the pathway in Pyrococcus furiosus, the enzyme acts instead to generate carbamoyl phosphate.
The seed alignment for this model includes experimentally confirmed examples from a set of phylogenetically distinct species. In a neighbor-joining tree constructed from an alignment of candidate carbamate kinases and several acetylglutamate kinases, the latter group forms a clear outgroup which roots the tree of carbamate kinase-like proteins. This analysis suggests that in E. coli, the ArcC paralog YqeA may be a second isozyme, while the paralog YahI branches as an outlier and is less likely to be an authentic carbamate kinase. The homolog from Mycoplasma pneumoniae likewise branches outside the set containing known carbamate kinases and also scores below the trusted cutoff.
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| References | A2 hmmalign
SE COG
AL clustalw_manual
DR EXPERIMENTAL; GP|2764613|emb|CAA04684.1||AJ001330; Lactobacillus sake
DR EXPERIMENTAL; EGAD|43354|45784; Halobacterium salinarium
DR EXPERIMENTAL; EGAD|9324|9129; Pseudomonas aeruginosa
DR EXPERIMENTAL; GP|4102922|gb|AAD13336.1||AF017784; Giardia intestinalis
DR EXPERIMENTAL; GP|3687419|emb|CAA76780.1||Y17554; Bacillus licheniformis
RM 99278397
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| Genome Property | GenProp0639: arginine degradation via citrulline, ATP-generating (HMM) |
| | GenProp0687: allantoin catabolism to oxamate and carbamoyl-phosphate (HMM) |
