| Accession | TIGR00745 |
| Name | apbA_panE |
| Function | 2-dehydropantoate 2-reductase |
| Trusted Cutoff | 141.35 |
| Domain Trusted Cutoff | 141.35 |
| Noise Cutoff | 91.40 |
| Domain Noise Cutoff | 91.40 |
| Isology Type | subfamily |
| EC Number | 1.1.1.- |
| HMM Length | 305 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Pantothenate and coenzyme A |
| Gene Ontology Term | GO:0008677: 2-dehydropantoate 2-reductase activity molecular_function |
| | GO:0015940: pantothenate biosynthetic process biological_process |
| Author | Haft DH, Loftus BJ |
| Entry Date | Mar 2 2000 2:33PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM describes enzymes that perform as 2-dehydropantoate 2-reductase, one of four enzymes required for the de novo biosynthesis of pantothenate (vitamin B5) from Asp and 2-oxoisovalerate. Although few members of the seed alignment are characterized experimentally, nearly all from complete genomes are found in a genome-wide (but not local) context of all three other pantothenate-biosynthetic enzymes (TIGR00222, TIGR00018, TIGR00223). The gene encoding this enzyme is designated apbA in Salmonella typhimurium and panE in Escherichia coli; this protein functions as a monomer and functions in the alternative pyrimidine biosynthetic, or APB, pathway, used to synthesize the pyrimidine moiety of thiamine. Note, synthesis of the pyrimidine moiety of thiamine occurs either via the first five steps in de novo purine biosynthesis, which uses the pur gene products, or through the APB pathway. Note that this family includes both NADH and NADPH-dependent enzymes, and enzymes with broad specificity, such as a D-mandelate dehydrogease that is also a 2-dehydropantoate 2-reductase. |
| References | DR InterPro; IPR003710
RN [1]
RM PMID:9721324
RT The panE gene, encoding ketopantoate reductase, maps at 10 minutes and is allelic to apbA in Salmonella typhimurium.
RA Frodyma ME, Downs D
RL J Bacteriol 1998 Sep;180(17):4757-9
RN [2]
RM PMID:18391442
RT A new family of D-2-hydroxyacid dehydrogenases that comprises D-mandelate dehydrogenases and 2-ketopantoate reductases.
RA Wada Y, Iwai S, Tamura Y, Ando T, Shinoda T, Arai K, Taguchi H
RL Biosci Biotechnol Biochem. 2008 Apr;72(4):1087-94. |
| Genome Property | GenProp0124: pantothenate biosynthesis from aspartate and 2-oxoisovalerate (HMM) |
