HMM Summary Page: TIGR00744

FunctionROK family protein (putative glucokinase)
Trusted Cutoff260.35
Domain Trusted Cutoff260.35
Noise Cutoff178.90
Domain Noise Cutoff178.90
Isology Typesubfamily
HMM Length318
Mainrole CategoryUnknown function
Subrole CategoryGeneral
AuthorHaft DH
Entry DateMar 2 2000 2:32PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this HMM all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution.
ReferencesA2 hmmalign AL msa_ncbi RM 95039896 RT Evolutionary relationships between sugar kinases and transcriptional repressors in bacteria. RA Titgemeyer F, Reizer J, Reizer A, Saier MH Jr RL Microbiology 1994 Sep;140 ( Pt 9):2349-54