HMM Summary Page: TIGR00742

FunctiontRNA dihydrouridine synthase A
Gene SymboldusA
Trusted Cutoff397.20
Domain Trusted Cutoff397.20
Noise Cutoff118.35
Domain Noise Cutoff118.35
Isology Typesubfamily
EC Number1.-.-.-
HMM Length318
Mainrole CategoryProtein synthesis
Subrole CategorytRNA and rRNA base modification
AuthorHaft DH
Entry DateFeb 22 2000 11:32AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents one branch of COG0042 (Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family). It represents a distinct subset by a set of shared unique motifs, a conserved pattern of insertions/deletions relative to other nifR3 homologs, and by subclustering based on cross-genome bidirectional best hits. Members are found in species as diverse as the proteobacteria, a spirochete, a cyanobacterium, and Deinococcus radiodurans. NifR3 itself, a protein of unknown function associated with nitrogen regulation in Rhodobacter capsulatus, is not a member of this branch. Members of this family show a distant relationship to alpha/beta (TIM) barrel enzymes such as dihydroorotate dehydrogenase and glycolate oxidase.
ReferencesRN [1] RM PMID: 12003496 RT A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA. RA Xing F, Martzen MR, Phizicky EM. RL RNA. 2002 Mar;8(3):370-81.