HMM Summary Page: TIGR00741

Functionribosomal subunit interface protein
Gene SymbolraiA
Trusted Cutoff40.90
Domain Trusted Cutoff40.90
Noise Cutoff29.50
Domain Noise Cutoff29.50
Isology Typeequivalog_domain
HMM Length102
Mainrole CategoryProtein synthesis
Subrole CategoryTranslation factors
Gene Ontology TermGO:0005840: ribosome cellular_component
GO:0009386: translational attenuation biological_process
GO:0022626: cytosolic ribosome cellular_component
GO:0045182: translation regulator activity molecular_function
AuthorHaft DH
Entry DateFeb 22 2000 11:32AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model includes a small protein encoded by one of two genes, both downstream of the gene rpoN for sigma 54, whose deletion leads to increased expression from sigma 54-dependent promoters. It also includes the N-terminal half of a light-repressed protein LtrA of Synechococcus PCC 7002 and the N-terminal region (after removal of the transit peptide) of a larger plastid-specific ribosomal protein of spinach. The member of this family from E. coli is now recognized as a protein at the interace between ribosomal large and small subunits, with about 1/3 as many copies per cell as the number of ribosomes.
ReferencesA2 hmmalign AL clustalw_manual RN [1] RM 20006236 RT A protein residing at the subunit interface of the bacterial ribosome. RA Agafonov DE, Kolb VA, Nazimov IV, Spirin AS RL Proc Natl Acad Sci U S A 1999 Oct 26;96(22):12345-9 RN [2] RM 90158124 RT Mutations in genes downstream of the rpoN gene (encoding sigma 54) of Klebsiella pneumoniae affect expression from sigma 54-dependent promoters. RA Merrick MJ, Coppard JR RL Mol Microbiol 1989 Dec;3(12):1765-75