HMM Summary Page: TIGR00740
| Accession | TIGR00740 |
| Name | TIGR00740 |
| Function | tRNA (cmo5U34)-methyltransferase |
| Gene Symbol | cmoA |
| Trusted Cutoff | 193.30 |
| Domain Trusted Cutoff | 193.30 |
| Noise Cutoff | 112.00 |
| Domain Noise Cutoff | 112.00 |
| Isology Type | equivalog |
| EC Number | 2.1.1.- |
| HMM Length | 239 |
| Mainrole Category | Unknown function |
| Subrole Category | Enzymes of unknown specificity |
| Gene Ontology Term | GO:0008168: methyltransferase activity molecular_function |
| Author | Haft DH |
| Entry Date | Feb 22 2000 11:32AM |
| Last Modified | Apr 15 2014 12:02PM |
| Comment | This tRNA methyltransferase is involved, together with cmoB, in preparing the uridine-5-oxyacetic acid (cmo5U) at position 34. |
| References | RN [1] RM PMID:15383682 RT The modified wobble nucleoside uridine-5-oxyacetic acid in tRNAPro(cmo5UGG) promotes reading of all four proline codons in vivo. RA Nasvall SJ, Chen P, Bjork GR RL RNA. 2004 Oct;10(10):1662-73. RN [2] RM PMID:23676670 RT Structure-guided discovery of the metabolite carboxy-SAM that modulates tRNA function. RA Kim J, Xiao H, Bonanno JB, Kalyanaraman C, Brown S, Tang X, Al-Obaidi NF, Patskovsky Y, Babbitt PC, Jacobson MP, Lee YS, Almo SC RL Nature. 2013 Jun 6;498(7452):123-6. doi: 10.1038/nature12180. DR HAMAP; MF_01589; 120 of 124 |
| Genome Property | GenProp1077: tRNA(Pro) cmo5UGG modification (HMM) |