HMM Summary Page: TIGR00737

Functionputative TIM-barrel protein, nifR3 family
Trusted Cutoff293.30
Domain Trusted Cutoff293.30
Noise Cutoff184.95
Domain Noise Cutoff184.95
Isology Typesubfamily
HMM Length319
Mainrole CategoryUnknown function
Subrole CategoryGeneral
AuthorHaft DH
Entry DateFeb 22 2000 11:32AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents one branch of COG0042 (Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family). This branch includes NifR3 itself, from Rhodobacter capsulatus. It excludes a broadly distributed but more sparsely populated subfamily that contains sll0926 from Synechocystis PCC6803, HI0634 from Haemophilus influenzae, and BB0225 from Borrelia burgdorferi. It also excludes a shorter and more distant archaeal subfamily. The function of nifR3, a member of this family, is unknown, but it is found in an operon with nitrogen-sensing two component regulators in Rhodobacter capsulatus. Members of this family show a distant relationship to alpha/beta (TIM) barrel enzymes such as dihydroorotate dehydrogenase and glycolate oxidase.
ReferencesA2 hmmalign AL clustalw RM 98409323 RT Evolution of new protein function: recombinational enhancer Fis originated by horizontal gene transfer from the transcriptional regulator NtrC. RA Morett E, Bork P RL FEBS Lett 1998 Aug 14;433(1-2):108-12