HMM Summary Page: TIGR00733

Functionoligopeptide transporter, OPT family
Trusted Cutoff182.50
Domain Trusted Cutoff182.50
Noise Cutoff77.15
Domain Noise Cutoff77.15
Isology Typeequivalog
HMM Length589
Mainrole CategoryTransport and binding proteins
Subrole CategoryAmino acids, peptides and amines
Gene Ontology TermGO:0006857: oligopeptide transport biological_process
GO:0015198: oligopeptide transporter activity molecular_function
GO:0016020: membrane cellular_component
AuthorHaft DH
Entry DateFeb 22 2000 11:31AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein represents a small family of integral membrane proteins from Gram-negative bacteria, a Gram-positive bacteria, and an archaeal species. Members of this family contain 15 to 18 GES predicted transmembrane regions, and this family has extensive homology to a family of yeast tetrapeptide transporters, including isp4 (Schizosaccharomyces pombe) and Opt1 (Candida albicans). EspB, an apparent equivalog from Myxococcus xanthus, shares an operon with a two component system regulatory protein, and is required for the normal timing of sporulation after the aggregation of cells. This is consistent with a role in transporting oligopeptides as signals across the membrane.
ReferencesRN [1] RM 20032045 RT Sporulation timing in Myxococcus xanthus is controlled by the espAB locus. RA Cho K, Zusman DR RL Mol Microbiol 1999 Nov;34(4):714-25 RN [2] RM 98305694 RT Schizosaccharomyces pombe isp4 encodes a transporter representing a novel family of oligopeptide transporters. RA Lubkowitz MA, Barnes D, Breslav M, Burchfield A, Naider F, Becker JM RL Mol Microbiol 1998 May;28(4):729-41