HMM Summary Page: TIGR00731

Functionribosomal protein bL25, Ctc-form
Trusted Cutoff73.10
Domain Trusted Cutoff73.10
Noise Cutoff70.35
Domain Noise Cutoff70.35
Isology Typeequivalog
HMM Length176
Mainrole CategoryProtein synthesis
Subrole CategoryRibosomal proteins: synthesis and modification
Gene Ontology TermGO:0000315: organellar large ribosomal subunit cellular_component
GO:0003735: structural constituent of ribosome molecular_function
GO:0006412: translation biological_process
GO:0006950: response to stress biological_process
GO:0008097: 5S rRNA binding molecular_function
GO:0022625: cytosolic large ribosomal subunit cellular_component
AuthorHaft DH
Entry DateFeb 22 2000 11:31AM
Last ModifiedSep 4 2014 11:49AM
CommentThis HMM models a family of proteins with full-length homology to the general stress protein Ctc of Bacillus subtilis, a mesophile, and ribosomal protein TL5 of Thermus thermophilus, a thermophile. Ribosomal protein L25 of Escherichia coli and H. influenzae appear to be orthologous but consist only of the N-terminal half of Ctc and TL5. Both short (L25-like) and full-length (CTC-like) members of this family bind the E-loop of bacterial 5S rRNA. This protein appears to be restricted to bacteria and organelles, and consists of at most one copy per prokaryotic genome.Ctc of Bacillus subtilis has now been localized to ribosomes and can be viewed as the long form, or Ctc form, of L25. The C-terminal domain of sll1824, an apparent L25 of Synechocystis PCC6803, matches the N-terminal domain of this family. Examples of L25 and Ctc are not separated by a UPGMA tree built on the region of shared homology.
ReferencesAL clustalw_manual RN [1] RM 12432960 RT The general stress protein Ctc of Bacillus subtilis is a ribosomal protein. RA Schmalisch M, Langbein I, Stulke J. RL J Mol Microbiol Biotechnol. 2002 Sep;4(5):495-501. RN [2] RM 99283874 RN [3] RM 99016057 DR HAMAP; MF_01334; 297 of 298