HMM Summary Page: TIGR00729

Functionribonuclease HII
Gene SymbolrnhB
Trusted Cutoff123.30
Domain Trusted Cutoff123.30
Noise Cutoff97.80
Domain Noise Cutoff97.80
Isology Typeequivalog
EC Number3.1.26.4
HMM Length207
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0004523: ribonuclease H activity molecular_function
GO:0006401: RNA catabolic process biological_process
AuthorHaft DH
Entry DateFeb 22 2000 11:31AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme cleaves RNA from DNA-RNA hybrids. Archaeal members of this subfamily of RNase H are designated RNase HII and one has been shown to be active as a monomer. A member from Homo sapiens was characterized as RNase HI, large subunit.
ReferencesAL clustalw_manual DR EXPERIMENTAL; GP|3551209|dbj|BAA32803.1||AB012613; Pyrococcus kodakaraensis DR EXPERIMENTAL; GP|3334761|emb|CAB09725.1||Z97029; Homo sapiens RN [1] RM 99047566 RT Gene cloning and characterization of recombinant RNase HII from a hyperthermophilic archaeon. RA Haruki M, Hayashi K, Kochi T, Muroya A, Koga Y, Morikawa M, Imanaka T, Kanaya S RL J Bacteriol 1998 Dec;180(23):6207-14 RN [2] RM 99007233 RT Cloning of the cDNA encoding the large subunit of human RNase HI, a homologue of the prokaryotic RNase HII. RA Frank P, Braunshofer-Reiter C, Wintersberger U, Grimm R, Busen W RL Proc Natl Acad Sci U S A 1998 Oct 27;95(22):12872-7 DR HAMAP; MF_00052; 42 of 548