HMM Summary Page: TIGR00722

Functionhydrolyase, tartrate alpha subunit/fumarate domain protein, Fe-S type
Trusted Cutoff100.65
Domain Trusted Cutoff100.65
Noise Cutoff84.90
Domain Noise Cutoff84.90
Isology Typesubfamily_domain
HMM Length273
AuthorHaft DH
Entry DateFeb 1 2000 10:52AM
Last ModifiedFeb 14 2011 3:27PM
CommentA number of Fe-S cluster-containing hydro-lyases share a conserved motif, including argininosuccinate lyase, adenylosuccinate lyase, aspartase, class I fumarate hydratase (fumarase), and tartrate dehydratase (see PROSITE:PDOC00147). This model represents a subset of closely related proteins or modules, including the E. coli tartrate dehydratase alpha chain and the N-terminal region of the class I fumarase (where the C-terminal region is homologous to the tartrate dehydratase beta chain). The activity of archaeal proteins in this subfamily has not been established.
ReferencesA2 hmmalign AL clustalw DR PROSITE; PDOC00147; Fumarate lyases signature DR PFAM; PF00206; lyase_1