HMM Summary Page: TIGR00721

FunctionDNA-binding protein, Tfx family
Trusted Cutoff60.25
Domain Trusted Cutoff60.25
Noise Cutoff45.40
Domain Noise Cutoff45.40
Isology Typesubfamily
HMM Length137
Mainrole CategoryRegulatory functions
Subrole CategoryDNA interactions
AuthorHaft DH
Entry DateFeb 1 2000 10:52AM
Last ModifiedFeb 14 2011 3:27PM
CommentPSI-BLAST starting with one member of this family converges with significant hits only to other members of the family, which is restricted to the Archaea. Homology is strongest in the helix-turn-helix-containing N-terminal region. Tfx from Methanobacterium thermoautotrophicum is associated with the operon for molybdenum formyl-methanofuran dehydrogenase and binds a DNA sequence near its promoter.
ReferencesAL clustalw DR SWISSPROT; P56811 RM 99157570 RT The DNA binding protein Tfx from Methanobacterium thermoautotrophicum: structure, DNA binding properties and transcriptional regulation. RA Hochheimer A, Hedderich R, Thauer RK RL Mol Microbiol 1999 Jan;31(2):641-50 DR HAMAP; MF_00620; 10 of 10