HMM Summary Page: TIGR00718

FunctionL-serine dehydratase, iron-sulfur-dependent, alpha subunit
Gene SymbolsdaAA
Trusted Cutoff243.20
Domain Trusted Cutoff243.20
Noise Cutoff201.50
Domain Noise Cutoff201.50
Isology Typeequivalog
EC Number4.3.1.17
HMM Length300
Mainrole CategoryEnergy metabolism
Subrole CategoryAmino acids and amines
Gene Ontology TermGO:0003941: L-serine ammonia-lyase activity molecular_function
GO:0006094: gluconeogenesis biological_process
GO:0006565: L-serine catabolic process biological_process
AuthorHaft DH
Entry DateFeb 1 2000 10:52AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme is also called serine deaminase. L-serine dehydratase converts serine into pyruvate in the gluconeogenesis pathway from serine. This model describes the alpha chain of an iron-sulfur-dependent L-serine dehydratase, found in Bacillus subtilis. A fairly deep split in a UPGMA tree separates members of this family of alpha chains from the homologous region of single chain forms such as found in Escherichia coli. This family of enzymes is not homologous to the pyridoxal phosphate-dependent threonine deaminases and eukaryotic serine deaminases.
ReferencesDR EXPERIMENTAL; EGAD|154938|165375; Peptostreptococcus asaccharolyticus RM 97386436