HMM Summary Page: TIGR00715

Functionprecorrin-6x reductase
Gene SymbolcobK
Trusted Cutoff129.85
Domain Trusted Cutoff129.85
Noise Cutoff82.00
Domain Noise Cutoff82.00
Isology Typeequivalog
EC Number1.3.1.54
HMM Length256
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryHeme, porphyrin, and cobalamin
Gene Ontology TermGO:0005737: cytoplasm cellular_component
GO:0009236: cobalamin biosynthetic process biological_process
GO:0016994: precorrin-6A reductase activity molecular_function
AuthorHaft DH
Entry DateFeb 1 2000 10:52AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme catalyzes a step in cobalamin biosynthesis. It has been identified experimentally in Pseudomonas denitrificans and has been shown to be part of cobalamin biosynthetic operons in several other species. This enzyme was found to be a monomer by gel filtration.
ReferencesDR InterPro; IPR003723 DR PFAM; PF02571 RN [1] RM 92121090 RT Precorrin-6x reductase from Pseudomonas denitrificans: purification and characterization of the enzyme and identification of the structural gene. RA Blanche F, Thibaut D, Famechon A, Debussche L, Cameron B, Crouzet J RL J Bacteriol 1992 Feb;174(3):1036-42 DR EXPERIMENTAL; EGAD|134631|143617; Pseudomonas denitrificans
Genome PropertyGenProp0113: cobyrinic acid diamide biosynthesis, aerobic pathway (HMM)
GenProp0275: cobyrinic acid diamide biosynthesis, anaerobic pathway (HMM)