HMM Summary Page: TIGR00714

FunctionFe-S protein assembly co-chaperone HscB
Gene SymbolhscB
Trusted Cutoff46.75
Domain Trusted Cutoff46.75
Noise Cutoff44.70
Domain Noise Cutoff44.70
Isology Typeequivalog
HMM Length156
Mainrole CategoryProtein fate
Subrole CategoryProtein folding and stabilization
Gene Ontology TermGO:0005515: protein binding molecular_function
GO:0006457: protein folding biological_process
AuthorHaft DH
Entry DateFeb 1 2000 10:52AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes the small subunit, Hsc20 (20K heat shock cognate protein) of a pair of proteins Hsc66-Hsc20, related to the DnaK-DnaJ heat shock proteins, which also serve as molecular chaperones. Hsc20, unlike DnaJ, appears not to have chaperone activity on its own, but to act solely as a regulatory subunit for Hsc66 (i.e., to be a co-chaperone). The gene for Hsc20 in E. coli, hscB, is not induced by heat shock.
ReferencesAL clustalw_manual DR PFAM; PF00226; DnaJ RN [1] RM 99069337 RT The Hsc66-Hsc20 chaperone system in Escherichia coli: chaperone activity and interactions with the DnaK-DnaJ-grpE system. RA Silberg JJ, Hoff KG, Vickery LE RL J Bacteriol 1998 Dec;180(24):6617-24 DR EXPERIMENTAL; EGAD|6265|EC2527; Escherichia coli DR OUTGROUP; EGAD|155934|AA0494; Aquifex aeolicus DR OUTGROUP; EGAD|163242|RP184 DR HAMAP; MF_00682; 109 of 111
Genome PropertyGenProp0138: iron-sulfur cluster assembly iscSUA-hscBA-fdx system (HMM)