HMM Summary Page: TIGR00713

Gene SymbolhemL
Trusted Cutoff527.30
Domain Trusted Cutoff527.30
Noise Cutoff281.90
Domain Noise Cutoff281.90
Isology Typeequivalog
EC Number5.4.3.8
HMM Length423
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryHeme, porphyrin, and cobalamin
Gene Ontology TermGO:0005737: cytoplasm cellular_component
GO:0006779: porphyrin-containing compound biosynthetic process biological_process
GO:0042286: glutamate-1-semialdehyde 2,1-aminomutase activity molecular_function
AuthorHaft DH
Entry DateFeb 1 2000 10:52AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme, glutamate-1-semialdehyde-2,1-aminomutase (glutamate-1-semialdehyde aminotransferase, GSA aminotransferase), contains a pyridoxal phosphate attached at a Lys residue at position 283 of the seed alignment. It is in the family of class III aminotransferases.
ReferencesAL clustalw_manual DR PROSITE; PDOC00519; Aminotransferases class-III pyridoxal-phosphate attachment site DR PFAM; PF00202; Aminotransferases class-III pyridoxal-phosphate DR ECOCYC; EG10432; hemL DR EXPERIMENTAL; EGAD|19989|EC0154; Escherichia coli DR EXPERIMENTAL; EGAD|10151|9957; Propionibacterium freudenreichii DR EXPERIMENTAL; EGAD|76320|82044; Hordeum vulgare DR HAMAP; MF_00375; 349 of 360
Genome PropertyGenProp0217: 5-aminolevulinate biosynthesis (glutamate pathway) (HMM)