HMM Summary Page: TIGR00711

Functiondrug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family
Trusted Cutoff230.20
Domain Trusted Cutoff230.20
Noise Cutoff175.95
Domain Noise Cutoff175.95
Isology Typesubfamily
HMM Length485
Mainrole CategoryCellular processes
Subrole CategoryToxin production and resistance
Gene Ontology TermGO:0005887: integral to plasma membrane cellular_component
GO:0006855: drug transmembrane transport biological_process
GO:0015307: drug:hydrogen antiporter activity molecular_function
GO:0042493: response to drug biological_process
AuthorHaft DH
Entry DateFeb 1 2000 10:52AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli.
ReferencesA2 hmmalign AL clustalw RN [1] RM 98125732 RN [2] RM 93028382