HMM Summary Page: TIGR00710

Functiondrug resistance transporter, Bcr/CflA subfamily
Trusted Cutoff200.90
Domain Trusted Cutoff200.90
Noise Cutoff188.55
Domain Noise Cutoff188.55
Isology Typesubfamily
HMM Length385
Gene Ontology TermGO:0015238: drug transmembrane transporter activity molecular_function
GO:0015893: drug transport biological_process
AuthorHaft DH
Entry DateFeb 1 2000 10:52AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
ReferencesA2 hmmalign DR SWISSPROT; P28246 DR PFAM; PF00083; sugar_tr RM 93252267 RT Cloning and sequence analysis of an Escherichia coli gene conferring bicyclomycin resistance. RA Bentley J, Hyatt LS, Ainley K, Parish JH, Herbert RB, White GR RL Gene 1993 May 15;127(1):117-20