HMM Summary Page: TIGR00709

Function2,4-diaminobutyrate 4-transaminase
Trusted Cutoff401.60
Domain Trusted Cutoff401.60
Noise Cutoff334.40
Domain Noise Cutoff334.40
Isology Typesubfamily
EC Number2.6.1.-
HMM Length442
Mainrole CategoryCentral intermediary metabolism
Subrole CategoryOther
Gene Ontology TermGO:0008483: transaminase activity molecular_function
GO:0019491: ectoine biosynthetic process biological_process
AuthorHaft DH
Entry DateFeb 1 2000 10:52AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family consists of L-diaminobutyric acid transaminases. This general designation covers both (diaminobutyrate-2-oxoglutarate transaminase, which uses glutamate as the amino donor in DABA biosynthesis), and (diaminobutyrate--pyruvate transaminase, which uses alanine as the amino donor). Most members with known function are, and at least some annotations as in current databases at time of model revision are incorrect. A distinct branch of this family contains examples of nearly all of which are involved in ectoine biosynthesis. A related enzyme is 4-aminobutyrate aminotransferase (EC, also called GABA transaminase. These enzymes all are pyridoxal phosphate-containing class III aminotransferase.
ReferencesAL clustalw A2 hmmalign DR PROSITE; PDOC00519; Aminotransferases class-III pyridoxal-phosphate attachment site DR PFAM; PF00202; Aminotransferases class-III pyridoxal-phosphate RN [1] RM 97405910 RN [2] RM 98173550 DR EXPERIMENTAL; EGAD|27972|HI0949; Haemophilus influenzae DR EXPERIMENTAL; EGAD|149638|159677; Acinetobacter baumannii DR EXPERIMENTAL; EGAD|149640|159679; Marinococcus halophilus DR OUTGROUP; EGAD|18860|EC2662 DR OUTGROUP; EGAD|170770|APE0457