| Accession | TIGR00709 |
| Name | dat |
| Function | 2,4-diaminobutyrate 4-transaminase |
| Trusted Cutoff | 401.60 |
| Domain Trusted Cutoff | 401.60 |
| Noise Cutoff | 334.40 |
| Domain Noise Cutoff | 334.40 |
| Isology Type | subfamily |
| EC Number | 2.6.1.- |
| HMM Length | 442 |
| Mainrole Category | Central intermediary metabolism |
| Subrole Category | Other |
| Gene Ontology Term | GO:0008483: transaminase activity molecular_function |
| | GO:0019491: ectoine biosynthetic process biological_process |
| Author | Haft DH |
| Entry Date | Feb 1 2000 10:52AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This family consists of L-diaminobutyric acid transaminases. This general designation covers both 2.6.1.76 (diaminobutyrate-2-oxoglutarate transaminase, which uses glutamate as the amino donor in DABA biosynthesis), and 2.6.1.46 (diaminobutyrate--pyruvate transaminase, which uses alanine as the amino donor). Most members with known function are 2.6.1.76, and at least some annotations as 2.6.1.46 in current databases at time of model revision are incorrect. A distinct branch of this family contains examples of 2.6.1.76 nearly all of which are involved in ectoine biosynthesis. A related enzyme is 4-aminobutyrate aminotransferase (EC 2.6.1.19), also called GABA transaminase. These enzymes all are pyridoxal phosphate-containing class III aminotransferase. |
| References | AL clustalw
A2 hmmalign
DR PROSITE; PDOC00519; Aminotransferases class-III pyridoxal-phosphate attachment site
DR PFAM; PF00202; Aminotransferases class-III pyridoxal-phosphate
RN [1]
RM 97405910
RN [2]
RM 98173550
DR EXPERIMENTAL; EGAD|27972|HI0949; Haemophilus influenzae
DR EXPERIMENTAL; EGAD|149638|159677; Acinetobacter baumannii
DR EXPERIMENTAL; EGAD|149640|159679; Marinococcus halophilus
DR OUTGROUP; EGAD|18860|EC2662
DR OUTGROUP; EGAD|170770|APE0457 |
