HMM Summary Page: TIGR00707

Functiontransaminase, acetylornithine/succinylornithine family
Trusted Cutoff410.05
Domain Trusted Cutoff410.05
Noise Cutoff397.55
Domain Noise Cutoff397.55
Isology Typesubfamily
HMM Length381
AuthorHaft DH
Entry DateFeb 1 2000 10:52AM
Last ModifiedSep 16 2014 4:02PM
CommentThis family of proteins, for which ornithine aminotransferases form an outgroup, consists mostly of proteins designated acetylornithine aminotransferase. However, the two very closely related members from E. coli are assigned different enzymatic activities. One is acetylornithine aminotransferase (EC, ArgD, an enzyme of arginine biosynthesis, while another is succinylornithine aminotransferase, an enzyme of the arginine succinyltransferase pathway, an ammonia-generating pathway of arginine catabolism (See MEDLINE:98361920). Members of this family may also act on ornithine, like ornithine aminotransferase (EC (see MEDLINE:90337349) and on succinyldiaminopimelate, like N-succinyldiaminopmelate-aminotransferase (EC, DapC, an enzyme of lysine biosynthesis) (see MEDLINE:99175097)
ReferencesDR PROSITE; PDOC00519; Aminotransferases class-III pyridoxal-phosphate attachment site DR PFAM; PF00202; Aminotransferases class-III pyridoxal-phosphate DR OUTGROUP; EGAD|21835|BS4028; ornithine aminotransferase, B. subtilis DR OUTGROUP; EGAD|54736|YLR438W; ornithine aminotransferase, yeast DR EXPERIMENTAL; EGAD|55794|YOL140W; Saccharomyces cerevisiae DR EXPERIMENTAL; EGAD|13014|EC3359; Escherichia coli DR EC;; acetylornithine aminotransferase DR EC; 2.6.1.-; succinylornithine aminotransferase RN [1] RM 98361920 RN [2] RM 90337349 RN [3] RM 99175097 DR HAMAP; MF_01173; 15 of 15
Genome PropertyGenProp0118: ornithine biosynthesis from glutamate, acetylated branch (HMM)
GenProp0193: lysine biosynthesis via alpha-aminoadipate (AAA pathway) (HMM)